Nickel-Catalyzed Regiodivergent Reductive Hydroarylation of Styrenes

Abstract We report a ligand-controlled nickel-catalyzed reductive hydroarylation of styrenes with predictable and controllable regioselectivity. With a diamine ligand, the reaction produces selective linear hydroarylation products. Alternatively, with a chiral PyrOx ligand, branch-selective enantioe...

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Bibliographic Details
Published in:Synlett 2021-10, Vol.32 (16), p.1647-1651
Main Authors: Xue, Yuhang, Chen, Jian, Song, Peihong, He, Yuli, Zhu, Shaolin
Format: Article
Language:English
Subjects:
cluster
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Summary:Abstract We report a ligand-controlled nickel-catalyzed reductive hydroarylation of styrenes with predictable and controllable regioselectivity. With a diamine ligand, the reaction produces selective linear hydroarylation products. Alternatively, with a chiral PyrOx ligand, branch-selective enantioenriched 1,1-diarylalkane products are obtained. Preliminary mechanistic results are consistent with a reductive Heck process.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1523-3228