Visible-Light-Mediated Direct Amidation of Arenes and Hetero­arenes with N-Aminopyridinium Salts

Abstract A novel photoinduced strategy has been developed for the C–H amidation of aromatics and heteroaromatics by using benzamide radicals with free NH groups generated from N -amidopyridinium salts under visible-light irradiation. The new mode of activation of N -amidopyridinium salts proceeds ef...

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Bibliographic Details
Published in:Synlett 2022-09, Vol.33 (15), p.1551-1555
Main Authors: Xia, Cencen, Hao, Xinyu, Jin, Kun, Zhang, Rong, Duan, Chunying, Li, Yaming
Format: Article
Language:English
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Summary:Abstract A novel photoinduced strategy has been developed for the C–H amidation of aromatics and heteroaromatics by using benzamide radicals with free NH groups generated from N -amidopyridinium salts under visible-light irradiation. The new mode of activation of N -amidopyridinium salts proceeds efficiently under mild conditions to give various benzamide derivatives with free NH groups. In addition, oxazoline analogues, synthesized by the reaction with styrene, demonstrate a substantial range of prospective applications for this versatile protocol.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-1867-7228