A New Synthetic Strategy towards Bioactive Merosesquiterpenoids

Abstract The Diels-Alder cycloaddition of the labdane diene methyl­ TRANS-communate with various representative dienophiles has been studied. Based on this, a novel strategy for synthesizing bioactive merosesquiterpenes is reported. This methodology affords considerable atom and step economy and mak...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2008-12, Vol.2008 (24), p.4019-4027
Main Authors: Alvarez-Manzaneda, Enrique, Chahboun, Rachid, Cabrera, Eduardo, Alvarez, Esteban, Haidour, Ali, Ramos, Jose Miguel, Alvarez-Manzaneda, Ramón, Romera, Juan Luis, Escobar, Mari Angeles, Messouri, Ibtissam
Format: Article
Language:English
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Summary:Abstract The Diels-Alder cycloaddition of the labdane diene methyl­ TRANS-communate with various representative dienophiles has been studied. Based on this, a novel strategy for synthesizing bioactive merosesquiterpenes is reported. This methodology affords considerable atom and step economy and makes it feasible to prepare A-ring functionalised compounds. A study on the synthesis of the fungitoxic pycnanthuquinone C has been carried out.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0028-1083238