Synthesis of the CDK-Inhibitor Paullone by Cyclization of a Deprotonated α-Aminonitrile

Abstract Cyclization of a deprotonated N-monosubstituted α-aminonitrile obtained by Strecker reaction of a protected 2-amino­benzaldehyde with ethyl 2-aminocinnamate serves as the key step in a short synthesis of the tetracyclic ε-lactam paullone.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2008-12, Vol.2008 (24), p.3941-3944
Main Authors: Opatz, Till, Ferenc, Dorota
Format: Article
Language:English
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Summary:Abstract Cyclization of a deprotonated N-monosubstituted α-aminonitrile obtained by Strecker reaction of a protected 2-amino­benzaldehyde with ethyl 2-aminocinnamate serves as the key step in a short synthesis of the tetracyclic ε-lactam paullone.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0028-1083250