The Role of Ni-Carboxylate During Catalytic Asymmetric Iodolactonization Using PyBidine-Ni(OAc)2

Abstract The combination of a PyBidine-Ni(OAc) 2 complex with a catalytic amount of iodine efficiently catalyzed asymmetric iodo­lactonization to generate chiral iodolactones with up to 89% enantiomeric excess. The formation of an intermediate Ni-carboxylate species from the alkenyl carboxylic acid...

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Bibliographic Details
Published in:Synlett 2013-08, Vol.24 (16), p.2045-2048
Main Authors: Arai, Takayoshi, Kajikawa, Satoshi, Matsumura, Eri
Format: Article
Language:English
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Summary:Abstract The combination of a PyBidine-Ni(OAc) 2 complex with a catalytic amount of iodine efficiently catalyzed asymmetric iodo­lactonization to generate chiral iodolactones with up to 89% enantiomeric excess. The formation of an intermediate Ni-carboxylate species from the alkenyl carboxylic acid is a key role in promoting the iodolactonization.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1339676