Ruthenium-Catalyzed Oxidative C–H Bond Alkenylation of 2-Phenylimidazo[1,2-a]pyridine

Abstract Monoalkenylation of sp 2 C–H bonds directed by the innate reactivity of imidazo[1,2- a ]pyridine to afford 2-(2′-alkenylphenyl)imidazo[1,2- a ]pyridine with high levels of diastereoselectivity is described. The methodology is employed to generate di-substituted alkenes by using a cationic r...

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Bibliographic Details
Published in:Synlett 2015-07, Vol.26 (12), p.1671-1676
Main Authors: Sawant, Devesh, Singh, Iqubal, Tulsyan, Gaurav, Abbagani, Kishor, Pardasani, Ram T.
Format: Article
Language:English
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Summary:Abstract Monoalkenylation of sp 2 C–H bonds directed by the innate reactivity of imidazo[1,2- a ]pyridine to afford 2-(2′-alkenylphenyl)imidazo[1,2- a ]pyridine with high levels of diastereoselectivity is described. The methodology is employed to generate di-substituted alkenes by using a cationic ruthenium(II) catalyst in the presence of AgSbF 6 and Cu(OAc) 2 ·H 2 O under air.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0034-1380746