Modular Regiospecific Synthesis of Nitrated Fatty Acids

Abstract Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building bloc...

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Published in:Synthesis (Stuttgart) 2017-02, Vol.49 (3), p.615-636
Main Authors: Hock, Katharina J., Grimmer, Jennifer, Göbel, Dominik, Gasaya, George Gichogo T., Roos, Jessica, Maucher, Isabelle V., Kühn, Benjamin, Fettel, Jasmin, Maier, Thorsten J., Manolikakes, Georg
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container_end_page 636
container_issue 3
container_start_page 615
container_title Synthesis (Stuttgart)
container_volume 49
creator Hock, Katharina J.
Grimmer, Jennifer
Göbel, Dominik
Gasaya, George Gichogo T.
Roos, Jessica
Maucher, Isabelle V.
Kühn, Benjamin
Fettel, Jasmin
Maier, Thorsten J.
Manolikakes, Georg
description Abstract Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks and a Henry reaction/Burgess dehydration sequence for the formation of the key nitroalkene moiety.
doi_str_mv 10.1055/s-0036-1588314
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title Modular Regiospecific Synthesis of Nitrated Fatty Acids
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