Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N-Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes

Abstract An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired produc...

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Published in:Synlett 2020-07, Vol.31 (11), p.1102-1106
Main Authors: Yao, Ming, Zhang, Jingjing, Yang, Sen, Liu, E, Xiong, Hangxing
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container_end_page 1106
container_issue 11
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container_title Synlett
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creator Yao, Ming
Zhang, Jingjing
Yang, Sen
Liu, E
Xiong, Hangxing
description Abstract An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99%).
doi_str_mv 10.1055/s-0040-1708002
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title Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N-Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes
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