Formal Synthesis of (+)-Anatoxin-a by Asymmetric [2+2] Cycloaddition

Abstract A formal asymmetric synthesis of (+)-anatoxin-a, a neurotoxic alkaloid from ANABAENA FLOS AQUAE, has been achieved through a highly diastereoselective [2+2] cycloaddition of dichloroketene with a chiral enol ether.

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Bibliographic Details
Published in:Synlett 2005-05, Vol.2005 (8), p.1328-1330
Main Authors: Muniz, Mauro Neves, Kanazawa, Alice, Greene, Andrew E.
Format: Article
Language:English
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Summary:Abstract A formal asymmetric synthesis of (+)-anatoxin-a, a neurotoxic alkaloid from ANABAENA FLOS AQUAE, has been achieved through a highly diastereoselective [2+2] cycloaddition of dichloroketene with a chiral enol ether.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-868482