Synthesis of N-Modified 4-Aminopyridine-3-carboxylates by Ring ­Transformation

Abstract 3-Methyl-5-nitropyrimidin-4(3H)-one reacted with enaminones to cause the ring transformation leading to functionalized 4-aminopyridines. Various kinds of amino groups can be introduced at the 4-position by modifying the enaminones. The modification of its vicinal positions was also possible...

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Bibliographic Details
Published in:Synlett 2006-06, Vol.2006 (9), p.1437-1439
Main Authors: Nishiwaki, Nagatoshi, Nishimoto, Toyosato, Tamura, Mina, Ariga, Masahiro
Format: Article
Language:English
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Summary:Abstract 3-Methyl-5-nitropyrimidin-4(3H)-one reacted with enaminones to cause the ring transformation leading to functionalized 4-aminopyridines. Various kinds of amino groups can be introduced at the 4-position by modifying the enaminones. The modification of its vicinal positions was also possible. In addition, a bicyclic pyridine could be synthesized by making use of the ­vicinal functionality of a 4-aminopyridine-3-carboxylic acid.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-941567