Synthesis of 4,5-Dihydroisoxazoles from N-Nitroso-4,5-dihydropyrazoles under Microwave Activation

Abstract Substituted bicyclic and spirocyclic N-nitroso-4,5-dihydropyrazoles eliminate nitrogen under microwave irradiation within 3-8 minutes in solvent (chlorobenzene-DMF and chlorobenzene-AcOH) or in solvent-free conditions (on SiO 2 ) to afford the corresponding 4,5-dihydroisoxazole derivatives....

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Bibliographic Details
Published in:Synlett 2007-05, Vol.2007 (8), p.1235-1238
Main Authors: Stepakov, Alexander V., Galkin, Ivan A., Kostikov, Rafael R., Starova, Galina L., Starikova, Zoya A., Molchanov, Alexander P.
Format: Article
Language:English
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Summary:Abstract Substituted bicyclic and spirocyclic N-nitroso-4,5-dihydropyrazoles eliminate nitrogen under microwave irradiation within 3-8 minutes in solvent (chlorobenzene-DMF and chlorobenzene-AcOH) or in solvent-free conditions (on SiO 2 ) to afford the corresponding 4,5-dihydroisoxazole derivatives. This methodology ­represents an improvement on thermolysis and allows 4,5-di­hydroisoxazole systems to be obtained in good yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-977455