Ophthalmic drops causing coma in an infant

A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects f...

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Bibliographic Details
Published in:The Journal of pediatrics 2001-03, Vol.138 (3), p.441-443
Main Authors: Berlin, Randall J., Lee, Uyen T., Samples, John R., Rich, Larry F., Tang-Liu, Diane D-S., Sing, Kimberly A., Steiner, Robert D.
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic alpha-Agonists - poisoning
Biological and medical sciences
Brimonidine Tartrate
Coma - complications
Coma - etiology
Coma - prevention & control
Drug toxicity and drugs side effects treatment
Eye Abnormalities - complications
Humans
Infant, Newborn
Male
Medical sciences
Ophthalmic Solutions - administration & dosage
Ophthalmic Solutions - poisoning
Pharmacology. Drug treatments
Practice Guidelines as Topic
Quinoxalines - administration & dosage
Quinoxalines - poisoning
Syndrome
Toxicity: cardiovascular system
Toxicity: nervous system and muscle
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Summary:A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects from the systemic absorption of topically applied ophthalmic agents in children. (J Pediatr 2001;138:441-3)
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2001.111319