Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

There is a growing appreciation for the contribution of platelets to immunity; however, our knowledge mostly relies on platelet functions associated with vascular injury and the prevention of bleeding. Circulating immune complexes (ICs) contribute to both chronic and acute inflammation in a multitud...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 2018-02, Vol.115 (7), p.E1550-E1559
Main Authors:	Cloutier, Nathalie, Allaeys, Isabelle, Marcoux, Genevieve, Machlus, Kellie R., Mailhot, Benoit, Zufferey, Anne, Levesque, Tania, Becker, Yann, Tessandier, Nicolas, Melki, Imene, Zhi, Huiying, Poirier, Guy, Rondina, Matthew T., Italiano, Joseph E., Flamand, Louis, McKenzie, Steven E., Cote, Francine, Nieswandt, Bernhard, Khan, Waliul I., Flick, Matthew J., Newman, Peter J., Lacroix, Steve, Fortin, Paul R., Boilard, Eric
Format:	Article
Language:	English
Subjects:	Adaptive immunity Adult Anaphylaxis Anaphylaxis - blood Anaphylaxis - genetics Anaphylaxis - immunology Animals Antigen-Antibody Complex - immunology Antigen-antibody complexes Biochemistry, Molecular Biology Biological Sciences Bleeding Blood circulation Blood platelets Blood Platelets - immunology Blood-brain barrier Degranulation Female Fibrinogen Granular materials Humans Immunity Immunology and Inflammation Inflammation Inflammatory response Injury prevention Life Sciences Lungs Male Mice Mice, Inbred C57BL Mice, Knockout Platelet Activation Platelet Count Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - immunology Platelets PNAS Plus Receptors, IgG - genetics Receptors, IgG - immunology Rodents Sepsis Serotonin Serotonin - immunology Shock Shock, Septic - blood Shock, Septic - genetics Shock, Septic - immunology Signaling Tissues Viremia Young Adult
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