Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found that the IL- 17 response was mediated by γδ T cells, which trafficked from lymph nodes to the infected skin to induce n...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 2019-05, Vol.116 (22), p.10917-10926
Main Authors:	Marchitto, Mark C., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Archer, Nathan K., Ortines, Roger V., Alphonse, Martin P., Marusina, Alina I., Merleev, Alexander A., Wang, Yu, Pinsker, Bret L., Byrd, Angel S., Brown, Isabelle D., Ravipati, Advaitaa, Zhang, Emily, Cai, Shuting S., Limjunyawong, Nathachit, Dong, Xinzhong, Yeaman, Michael R., Simon, Scott I., Shen, Wei, Durum, Scott K., O’Brien, Rebecca L., Maverakis, Emanual, Miller, Lloyd S.
Format:	Article
Language:	English
Subjects:	Amino acid sequence Amino acids Animals Biological Sciences Coding Complementarity Complementarity-determining region Complementarity-determining region 3 Cytokines Disease Models, Animal Gene sequencing Humans IL-1β Immunity Immunology and Inflammation Inflammation Interleukin 17 Interleukin 22 Interleukin-17 - physiology Lymph nodes Lymph Nodes - immunology Lymphatic system Lymphocytes Lymphocytes T Mice Nodes Peptides PNAS Plus Ribonucleic acid RNA Skin Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - pathogenicity T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology Tumor necrosis factor γ-Interferon
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