Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the globe after its emergence in Wuhan in December 2019. With no specific therapeutic and prophylactic options available, the virus has infected millions of people of which more than half a million succumbed to the vi...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (43), p.26955-26965
Main Authors: Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Velde, Greetje Vande, Neyts, Johan, Rocha-Pereira, Joana, Delang, Leen
Format: Article
Language:English
Subjects:
Amides - pharmacokinetics
Amides - therapeutic use
Animal models
Animals
Antiviral activity
Antiviral agents
Antiviral Agents - therapeutic use
Azithromycin
Betacoronavirus - drug effects
Biocompatibility
Biological Sciences
Chlorocebus aethiops
Clinical trials
Coronavirus Infections - drug therapy
Coronavirus Infections - virology
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Cricetinae
Disease Models, Animal
Disease prevention
Disease transmission
Disease Transmission, Infectious - prevention & control
Dose-Response Relationship, Drug
Drug dosages
Drug Evaluation, Preclinical
Female
Hamsters
Health services
Histopathology
Hydroxychloroquine
Hydroxychloroquine - pharmacokinetics
Hydroxychloroquine - therapeutic use
Infections
Lung - drug effects
Lung - pathology
Lung - virology
Lungs
Microbiology
Pharmacokinetics
Pyrazines - pharmacokinetics
Pyrazines - therapeutic use
Respiratory diseases
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Vero Cells
Viral diseases
Viral Load - drug effects
Viruses
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