Growth hormone–releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice

COVID-19 pneumonia causes acute lung injury and acute respiratory distress syndrome (ALI/ARDS) characterized by early pulmonary endothelial and epithelial injuries with altered pulmonary diffusing capacity and obstructive or restrictive physiology. Growth hormone–releasing hormone receptor (GHRH-R)...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2023-11, Vol.120 (48), p.1-11, Article e2308342120
Main Authors: Capcha, Jose M. Condor, Kamiar, Ali, Robleto, Emely, Saad, Ali G., Cui, Tengjiao, Wong, Amanda, Villano, Jason, Zhong, William, Pekosz, Andrew, Medina, Edgar, Cai, Renzhi, Sha, Wei, Ranek, Mark J., Webster, Keith A., Schally, Andrew V., Jackson, Robert M., Shehadeh, Lina A.
Format: Article
Language:English
Subjects:
Air flow
Animals
Bleomycin
COVID-19
COVID-19 - pathology
Disease Models, Animal
Female
Gene expression
Growth hormone-releasing hormone
Growth hormones
Heart diseases
Histopathology
Immune response
Infectivity
Inflammation
Inflammation - pathology
Injuries
Intercellular adhesion molecule 1
Lung - pathology
Lungs
Male
Mathematical models
Mice
Mice, Transgenic
Necroptosis
Parameters
Physiology
Plethysmography
Pneumonia
Proteins
Receptors
Respiration
Respiratory distress syndrome
Respiratory Distress Syndrome - pathology
Respiratory rate
Respiratory tract diseases
Sarcoidosis
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Weight
Weight Loss
Weight reduction
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