Genes for Synapsin I, a Neuronal Phosphoprotein, Map to Conserved Regions of Human and Murine X Chromosomes

Synapsin I is a neuron-specific phosphoprotein associated with the membranes of small synaptic vesicles. Its function is not entirely clear, but evidence points to a possible role in the regulation of neurotransmitter release. Its biosynthesis is under developmental control. Assignment of the human...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-11, Vol.83 (22), p.8679-8683
Main Authors: Yang-Feng, Teresa L., DeGennaro, Louis J., Francke, Uta
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Evolution
Cell lines
Chromosome Mapping
Chromosomes
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Genetic loci
Human X chromosome
Humans
Hybrid cells
Hybridity
In situ hybridization
Mice
Molecular and cellular biology
Molecular genetics
Muscular Dystrophies - genetics
Mutation
Nerve Tissue Proteins - genetics
Nervous System Diseases - genetics
Nucleic Acid Hybridization
Phosphoproteins - genetics
Synapsins
X Chromosome
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Summary:Synapsin I is a neuron-specific phosphoprotein associated with the membranes of small synaptic vesicles. Its function is not entirely clear, but evidence points to a possible role in the regulation of neurotransmitter release. Its biosynthesis is under developmental control. Assignment of the human synapsin I gene to the X chromosome at band Xp11 was accomplished by in situ hybridization, using a rat cDNA probe. Southern blot analysis of DNAs from a panel of human--Chinese hamster somatic cell hybrids with defined regions of the human X chromosome confirmed the in situ mapping data. The mouse synapsin I gene was assigned to the X chromosome, proximal to band XD, by Southern blot analysis of Chinese hamster--mouse somatic cell hybrids with normal or rearranged mouse X chromosomes. In situ chromosomal hybridization experiments localized the mouse synapsin I gene more precisely to bands XA1→ A4. These results add to the comparative gene map of mammalian species and support certain hypotheses regarding the evolutionary relationship between human and mouse X chromosomes. We hypothesize that the synapsin I gene could be mutated in human X-linked disorders with primary neuronal degeneration, such as the Rett syndrome.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.22.8679