Suppressive Regulatory T Cell Activity Is Potentiated by Glycogen Synthase Kinase 3β Inhibition

The mechanism by which regulatory T (Treg) cells suppress the immune response is not well defined. A recent study has shown that β-catenin prolongs Treg cell survival. Because β-catenin is regulated by glycogen synthase kinase 3β (GSK-3β)-directed phosphorylation, we focused on GSK-3β and the role i...

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Bibliographic Details
Published in:	The Journal of biological chemistry 2010-10, Vol.285 (43), p.32852-32859
Main Authors:	Graham, Jay A., Fray, Michael, de Haseth, Stephanie, Lee, Kang Mi, Lian, Moh-Moh, Chase, Catharine M., Madsen, Joren C., Markmann, James, Benichou, Gilles, Colvin, Robert B., Cosimi, A. Benedict, Deng, Shaoping, Kim, James, Alessandrini, Alessandro
Format:	Article
Language:	English
Subjects:	Glycogen Synthase Kinase 3 Immunology Immunosuppressor Lymphocyte Signal Transduction
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