Stereoselective total synthesis of (-)-curvularin

A concise total synthesis of (-)-Curvularin have been synthesized from commercially available (S)-(−)-propylene epoxide and (3,5-Dimethoxyphenyl)acetic acid. The key steps involved in the synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkylation of 1,3-dithiane and Yamaguchi macrolact...

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Bibliographic Details
Published in:Synthetic communications 2022-01, Vol.52 (1), p.37-42
Main Authors: Radha Krishna, Muniganti, Sridhar, Gattu, Syed, Tasqeeruddin, Jayaprakash, H. V.
Format: Article
Language:English
Subjects:
(-)-Curvularin
1,3-dithiane
grignard reaction
vilsmeier-haack formylation
yamaguchi macrolactonization
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Summary:A concise total synthesis of (-)-Curvularin have been synthesized from commercially available (S)-(−)-propylene epoxide and (3,5-Dimethoxyphenyl)acetic acid. The key steps involved in the synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2021.1979043