Synthetic strategies in development of 3-aroylimidazo[1,2-a]pyridines and 2-aroylimidazo[1,2-a]pyridines: A decade update

Imidazo[1,2-a]pyridines are privileged aza-fused heterocyclic scaffolds possessing wide range of applications in medicinal chemistry, organometallics and material science. Imidazo[1,2-a]pyridines functionalized with aroyl group are perceived for their therapeutic applications. However, inaccessibili...

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Published in:Synthetic communications 2022-05, Vol.52 (9-10), p.1209-1244
Main Authors: Kumbhar, Vikrant V., Khairnar, Bhushan B., Chaskar, Manohar G., Pawar, Ramdas A., Gugale, Gulab S.
Format: Article
Language:English
Subjects:
C-H functionalization
Chemists
Friedel-Crafts reaction
multicomponent reaction
Organometallic compounds
oxidative coupling
Pyridines
regioselective
Regioselectivity
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Summary:Imidazo[1,2-a]pyridines are privileged aza-fused heterocyclic scaffolds possessing wide range of applications in medicinal chemistry, organometallics and material science. Imidazo[1,2-a]pyridines functionalized with aroyl group are perceived for their therapeutic applications. However, inaccessibility of this aroylated imidazo[1,2-a]pyridine by Friedel-Crafts reaction had left chemists with an alternate of three-steps long and tiresome protocol as the only source. Hence, in this review we have discussed all the rigorous efforts made in last decade for regioselective and straightforward synthesis of 3-aroyl and 2-aroyl imidazo[1,2-a]pyridines from readily accessible precursors in step-economic pathway. Most importantly, it draws our attention towards the challenge of regioselective aroylation at C-2 position of imidazo[1,2-a]pyridines, as only three methods are reported till date.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2022.2056057