An alternate synthesis of sporiolide B from (R)-glyceraldehyde

In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation,...

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Published in:Synthetic communications 2023-08, Vol.53 (16), p.1333-1338
Main Authors: Kokkiligadda, Suresh Babu, Musunuri, Sivanadh, Syed, Tasqeeruddin, Maiti, Bhimcharan, Mandava Venkata, Basaveswara Rao
Format: Article
Language:English
Subjects:
12-membered lactones
Chemical synthesis
Grignard reaction
Grignard reactions
Metathesis
sporiolide B
Yamaguchi macrolactonization and ring closing metathesis
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container_end_page 1338
container_issue 16
container_start_page 1333
container_title Synthetic communications
container_volume 53
creator Kokkiligadda, Suresh Babu
Musunuri, Sivanadh
Syed, Tasqeeruddin
Maiti, Bhimcharan
Mandava Venkata, Basaveswara Rao
description In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps.
doi_str_mv 10.1080/00397911.2023.2220443
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source Taylor and Francis Science and Technology Collection
subjects 12-membered lactones
Chemical synthesis
Grignard reaction
Grignard reactions
Metathesis
sporiolide B
Yamaguchi macrolactonization and ring closing metathesis
title An alternate synthesis of sporiolide B from (R)-glyceraldehyde
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