Synthesis and Some Reactions of 4-Aroyl-3-Chloro-6-p-Tolylpyridazines

4-Aroyl-3-chloro-6-p-tolylpyridazines (3 a & b ) were prepared by the action of phosphorous oxychloride on (2). (3 a & b ) react with hydrazine hydrate to give the pyrazolinopyridazines (4 a & b ) and with hydroxylamine hydrochloride to give the isoxazolopyridazines (7 a & b ), respe...

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Bibliographic Details
Published in:Synthetic communications 1998-10, Vol.28 (19), p.3609-3618
Main Authors: FekryIsmail, M., E. A.Mustafa, O., A.Emara, S., A. Y.Derbala, H., Sallam, H. A.
Format: Article
Language:English
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Summary:4-Aroyl-3-chloro-6-p-tolylpyridazines (3 a & b ) were prepared by the action of phosphorous oxychloride on (2). (3 a & b ) react with hydrazine hydrate to give the pyrazolinopyridazines (4 a & b ) and with hydroxylamine hydrochloride to give the isoxazolopyridazines (7 a & b ), respectively. (4 b ) was also synthesized by the action of phosphorous oxychloride on the hydrazone (5). The reaction of (3 a & b ) with primary amines in boiling ethanol gives (8 a - e ), while their reaction with primary aromatic amines in the presence of solvent gives the Schiff's bases (9 a - c ).
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808004907