Electrospun polycaprolactone/gelatin/bioactive glass nanoscaffold for bone tissue engineering

Polycaprolactone scaffolds, polycaprolactone/gelatin, and polycaprolactone/gelatin/bioactive glass scaffolds were prepared with ratios of 50/50, 25/75, and 75/25 for polymers and 5 wt% for the bioactive glass via electrospinning and then were characterized using. The results indicated that by adding...

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Bibliographic Details
Published in:International journal of polymeric materials 2019-07, Vol.68 (10), p.607-615
Main Authors: Shirani, Keyvan, Nourbakhsh, Mohammad Sadegh, Rafienia, Mohammad
Format: Article
Language:English
Subjects:
Apatite
Bioactivity
Biocompatibility
Bioglass
Biological activity
Biomedical materials
Body fluids
bone tissue engineering
degradation behavior
electrospun scaffold
Gelatin
In vitro methods and tests
mechanical properties
Mechanical tests
Modulus of elasticity
nanocomposite
Polycaprolactone
Scaffolds
Submerging
Surgical implants
Tissue engineering
Ultimate tensile strength
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Summary:Polycaprolactone scaffolds, polycaprolactone/gelatin, and polycaprolactone/gelatin/bioactive glass scaffolds were prepared with ratios of 50/50, 25/75, and 75/25 for polymers and 5 wt% for the bioactive glass via electrospinning and then were characterized using. The results indicated that by adding gelatin and bioactive glass to polycaprolactone scaffold, the diameter of fiber decreased from 557 to 167 nm. The results showed growth of apatite layer on the scaffolds after immersion in simulated body fluid for 28 days. The results of mechanical test revealed that by adding bioactive glass to scaffolds, the ultimate tensile strength and Young's modulus increase about two folds.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2018.1482461