Metalloantibiotics: synthesis and antibacterial activity of ceftazidime metal complexes

Ceftazidime (Hceftaz) interacts with transition metal(II) ions to give octahedral [M(ceftaz)(H 2 O)Cl] complexes [M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Cd(II)] which were characterized by physicochemical and spectroscopic methods. The spectra indicated that the ligand is a multidentate chel...

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Bibliographic Details
Published in:Journal of coordination chemistry 2009-02, Vol.62 (4), p.613-621
Main Authors: Anacona, J. R., Patiño, Candy
Format: Article
Language:English
Subjects:
Ceftazidime
Metal complexes
Metalloantibiotics
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Summary:Ceftazidime (Hceftaz) interacts with transition metal(II) ions to give octahedral [M(ceftaz)(H 2 O)Cl] complexes [M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Cd(II)] which were characterized by physicochemical and spectroscopic methods. The spectra indicated that the ligand is a multidentate chelating agent. The complexes are insoluble in water and common organic solvents and probably have polymeric structures. The antibacterial activity of the metal complexes was found to be lower than that of free ceftazidime.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970802291480