Synthesis, characterization, DNA binding and cleavage activity of homoleptic zinc(II) β-oxodithioester chelate complexes

• Published in: Journal of coordination chemistry 2017-09, Vol.70 (18), p.3171-3185
• Main Authors: Yadav, Manoj Kumar, Maurya, Akhilendra Kumar, Rajput, Gunjan, Manar, Krishna Kumar, Vinayak, Manjula, Drew, Michael G. B., Singh, Nanhai
• Format: Article
• Language: English
• Subjects: Anticancer activity; DNA Binding; DNA Cleavage; zinc(II) β-oxodithioester
• ISSN: 0095-8972; 1029-0389
• DOI: 10.1080/00958972.2017.1377835

New homoleptic zinc(II) complexes, [Zn(L) 2 ], where L = methyl-3-hydroxy-(3-pyridyl)-2-propenedithioate L1 1, and methyl-3-hydroxy-(4-pyridyl)-2-propenedithioate L2 2, have been synthesized and characterized by elemental (C, H, and N) analysis, ESI-MS, and (IR, UV-vis, NMR) spectroscopy; the structure of 1 has been deduced by X-ray crystallography. The DNA binding and cleavage activity of the complexes have been studied. The cleavage potential of pBR322 DNA by 1 and 2 has been checked. Complex 1, which contains nitrogen of the pyridine group in the 3-position enhances DNA cleavage potential in the presence of ascorbic acid; however, the complex is protective against DNA cleavage in the presence of DMSO or H 2 O 2 . Also, 1 causes cytotoxicity against the MCF-7 breast cancer cell line. The efficient cytotoxic activity and DNA cleavage ability of 1 in the presence of ascorbic acid shows its potential anticancer properties and the need for further investigations of its potential as an anticancer drug.