The evolution of mature cystic teratomas of the ovary into squamous cell carcinoma: two case reports and review of the literature

Mature Cystic Teratomas (MCT) of the ovary or Dermoid Cysts are common benign tumours found in 10-20% of women. However, 0.2-2% of those cysts underwent malignant transformation. Squamous Cell Carcinoma (SCC) is the most frequent histological type reported in the literature.As 2021, there are limite...

Full description

Saved in:
Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2022-07, Vol.42 (5), p.838-841
Main Authors: Ziadeh, Hanane, Duforestel, Thierry, Bouredji, Kenza, Re, Daniel, Debono, Laurence, Zreik, Tony, Moufawad, Graziella, Ghaname, Wadih
Format: Article
Language:English
Subjects:
Cysts
gynaecological oncology
gynaecological surgery
Gynecological surgery
Mature Cystic Teratoma
Menopause
Ovarian cancer
Ovaries
Squamous Cell Carcinoma
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mature Cystic Teratomas (MCT) of the ovary or Dermoid Cysts are common benign tumours found in 10-20% of women. However, 0.2-2% of those cysts underwent malignant transformation. Squamous Cell Carcinoma (SCC) is the most frequent histological type reported in the literature.As 2021, there are limited reports of malignant tumours arising from MCT with no guidelines related to the management of these atypical cases. Herein, we describe two cases of MCT that evolved into SCC with different stages and prognosis and we review the current literature to date highlighting the potential risk of malignant transformation of these considered benign cysts and the need for strong evidence protocols for staging and treatment of this atypical entity. IMPACT STATEMENT What is already known on this subject? Mature Cystic Teratomas are found in 10-20% of women. However, a malignant behavior is observed in 2% of cases. What do the results of this study add? Our paper will describe two cases of malignant transformation of dermoid cyst in an effort to highlight the possible malignant risk of this entity and the need for specific management guidelines. What are the implications of these findings for clinical practice and/or further research? The prognosis of this converted cyst is very poor. By elaborating a standard management protocol for this tumour and operating every large cyst (>10 cm) in postmenopausal women, we may prevent this event.
ISSN:0144-3615
1364-6893
DOI:10.1080/01443615.2022.2035333