Circovirus-infected geese studied by in situ hybridization

It has now been established that circovirus infection is common in farmed geese, but little is known about the clinicopathological significance of such infections. Ten clinically diseased geese suspected of being infected by circovirus were studied by in situ hybridization using a goose circovirus D...

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Bibliographic Details
Published in:Avian pathology 2005-06, Vol.34 (3), p.227-232
Main Authors: Smyth, J, Soike, D, Moffett, D, Weston, J.H, Todd, D
Format: Article
Language:English
Subjects:
Animal diseases
animal pathology
Animals
bone marrow
bursa of Fabricius
Bursa of Fabricius - virology
Circoviridae Infections - veterinary
Circovirus
Circovirus - isolation & purification
disease detection
DNA, Viral
geese
Geese - virology
heart
histology
Hybridization
in situ hybridization
In Situ Hybridization - methods
In Situ Hybridization - veterinary
kidneys
liver
lungs
Pathology
poultry diseases
Poultry Diseases - virology
quantitative analysis
Sensitivity and Specificity
small intestine
spleen
thymus gland
Thymus Gland - virology
Tissue Distribution
viral diseases of animals and humans
Viruses
Wildfowl
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Summary:It has now been established that circovirus infection is common in farmed geese, but little is known about the clinicopathological significance of such infections. Ten clinically diseased geese suspected of being infected by circovirus were studied by in situ hybridization using a goose circovirus DNA probe. Circovirus DNA was demonstrated in the bursa of Fabricius (BF), spleen, thymus, bone marrow, liver, kidney, lung and heart, indicating that infection can be multisystemic. In some birds, virus DNA was present in very large quantities, most notably in the BF, liver and small intestine. With the exception of BF and thymus, there were no histological findings that would have suggested the presence of such quantities of circovirus DNA. In view of the very large quantities of virus DNA labelling present in some tissues, and by analogy to porcine circovirus type 2 infection and psittacine beak and feather virus infections, which are known to cause severe disease, and which have similar virus distribution to that found in our geese, it seems probable that the circovirus was important in the disease manifestations shown by the infected geese.
ISSN:0307-9457
1465-3338
DOI:10.1080/03079450500112419