Exploring the antibacterial, antibiofilm, and antivirulence activities of tea tree oil-containing nanoemulsion against carbapenem-resistant Serratia marcescens associated infections

Carbapenem-resistant Serratia marcescens (CRE-S. marcescens) has recently emerged as an opportunistic human pathogen that causes various nosocomial and respiratory tract infections. The prognosis for CRE-S. marcescens-related infections is very poor and these infections are difficult to treat. This...

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Published in:Biofouling (Chur, Switzerland) Switzerland), 2022-01, Vol.38 (1), p.100-117
Main Authors: Das, Shatabdi, Vishakha, Kumari, Banerjee, Satarupa, Nag, Debasish, Ganguli, Arnab
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial
Biofilms
Caenorhabditis elegans
carbapenem-resistance
Carbapenems - pharmacology
Humans
nanoemulsion
Serratia marcescens
tea tree oil
Tea Tree Oil - pharmacology
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Summary:Carbapenem-resistant Serratia marcescens (CRE-S. marcescens) has recently emerged as an opportunistic human pathogen that causes various nosocomial and respiratory tract infections. The prognosis for CRE-S. marcescens-related infections is very poor and these infections are difficult to treat. This study investigated the synthesis of tea tree oil nanoemulsion (TTO-NE) and its impact on CRE-S. marcescens both in vitro and in vivo. TTO-NE was characterized by dynamic light scattering (DLS) and effectively eradicated bacterial planktonic and sessile forms, reduced bacterial virulence factors, and generated reactive oxygen species (ROS) in the bacterial cell. Notably, TTO-NE was efficient in reducing the colonization of CRE-S. marcescens in a C. elegans in vivo model. The data suggest that TTO-NE might be an excellent tool to combat infections associated with CRE-S. marcescens.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2021.2022125