Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats

We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietar...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-06, Vol.84 (6), p.1232-1238
Main Authors: Adhikari, Sudhashree, Bhattarai, Keshab, Abe, Yasuhiro, Kira, Mayu, Fujitani, Mina, Miyada, Tomihiro, Kishida, Taro
Format: Article
Language:English
Subjects:
Animals
anorectic effect
Appetite Depressants - pharmacology
Daidzein
Dietary Supplements
Eating - drug effects
Equol - pharmacology
Female
Gastrectomy
gastric emptying
Gastric Emptying - drug effects
Gastroparesis - chemically induced
Isoflavones - pharmacology
Ovariectomy
Rats
Rats, Sprague-Dawley
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Summary:We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying. Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2020.1723404