Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index

Background. Since current clinical evidence indicates that conventional estrogen hormone therapy (HT) increases cardiovascular risk, alternatives to estrogens are growing in popularity, especially among high-risk populations. Objective. To determine the effect of Trifolium pratense-derived isoflavon...

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Bibliographic Details
Published in:Gynecological endocrinology 2008-01, Vol.24 (11), p.620-624
Main Authors: Chedraui, Peter, San Miguel, Glenda, Hidalgo, Luis, Morocho, Nancy, Ross, Susana
Format: Article
Language:English
Subjects:
Body Mass Index
cardiovascular risk
Double-Blind Method
dyslipidemia
Dyslipidemias - blood
Dyslipidemias - prevention & control
Female
Humans
Isoflavones
Isoflavones - therapeutic use
Lipids - blood
Middle Aged
obesity
Phytotherapy
Plant Extracts - therapeutic use
Postmenopause - blood
red clover
Trifolium
Trifolium pratense
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Summary:Background. Since current clinical evidence indicates that conventional estrogen hormone therapy (HT) increases cardiovascular risk, alternatives to estrogens are growing in popularity, especially among high-risk populations. Objective. To determine the effect of Trifolium pratense-derived isoflavone supplementation on the lipid profile of postmenopausal women with increased body mass index (BMI). Methods. Sixty postmenopausal women aged > 40 years, HT non-users, were randomly assigned to one of two groups: either two capsules of T. pratense (80 mg red clover isoflavones) daily for a 90-day period or placebo of equal design. After a 7-day washout period, medication was crossed-over for another 90 days. Total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein A (LpA) levels were assessed at baseline, 90 and 180 days. Women were divided into two groups: those with increased BMI (≥25 kg m2) and those with BMI < 25 kg m2. Results. Fifty-three women (88.3%) completed the trial. T. pratense isoflavone supplementation had a positive effect on the lipid profile of women with increased BMI, evidenced by a significant decrease in TC, LDL-C and LpA levels. Conclusions. Isoflavones derived from T. pratense are an attractive alternative therapeutic option for high-risk populations such as postmenopausal women with increased BMI and abnormal lipid profile.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590802288283