Phillyrin attenuates airway inflammation and Th2 cell activities in a mouse asthma model

Phillyrin is isolated from the fruit of Forsythia suspensa, and exhibits multiple pharmacological effects, including anti-tumor, anti-inflammation, and anti-oxidation activities. Here, we investigated whether phillyrin could alleviate airway hyperresponsiveness (AHR) and eosinophil infiltration in t...

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Bibliographic Details
Published in:Food and agricultural immunology 2023-12, Vol.34 (1)
Main Authors: Huang, Wen-Chung, Wu, Shu-Ju, Fang, Li-Wen, Lin, Tzu-Yung, Liou, Chian-Jiun
Format: Article
Language:English
Subjects:
Airway hyperresponsiveness
airway inflammation
Anticancer properties
Asthma
Bronchus
Cell culture
Chemokines
cytokine
Cytokines
eosinophil
Eotaxin
Helper cells
Hyperplasia
Infiltration
Inflammation
Interleukin 4
Lavage
Leukocytes (eosinophilic)
Lungs
Lymphocytes T
Metastases
Ovalbumin
Oxidation
phillyrin
Respiratory tract diseases
Tumor necrosis factor-α
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Summary:Phillyrin is isolated from the fruit of Forsythia suspensa, and exhibits multiple pharmacological effects, including anti-tumor, anti-inflammation, and anti-oxidation activities. Here, we investigated whether phillyrin could alleviate airway hyperresponsiveness (AHR) and eosinophil infiltration in the lungs of asthmatic mice, and mitigate inflammatory responses in tracheal epithelial BEAS-2B cells. IL-4/TNF-α-stimulated BEAS-2B cells were treated with various phillyrin doses. Female BALB/c mice were sensitised and challenged with ovalbumin (OVA), and then treated with intraperitoneal injection different phillyrin doses. In IL-4/TNF-α-stimulated BEAS-2B cells, phillyrin effectively reduced proinflammatory cytokines, chemokines, and eotaxin (CCL11) levels. In the lungs of asthmatic mice, phillyrin treatment relieved AHR, airway inflammation, eosinophil infiltration, and goblet cell hyperplasia. Phillyrin also reduced serum OVA-IgE, and Th2-associated cytokine levels in splenocyte culture medium, and in bronchoalveolar lavage fluid of asthmatic mice. Our results indicate that phillyrin attenuated airway inflammation and eosinophil infiltration in asthmatic mice by suppressing Th2 cytokine production.
ISSN:0954-0105
1465-3443
DOI:10.1080/09540105.2023.2231182