Radioprotective effect of mistletoe extract on intestinal toxicity: in vivo study using adult zebrafish

The intestine is a dose-limiting organ in the treatment of intra-abdominal cancer. We previously reported that the extract of mistletoe parasites on Quercus had a more potent radioprotective effect than amifostine in reducing the developmental toxicities of zebrafish embryos. In this study, radiopro...

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Published in:International journal of radiation biology 2023-05, Vol.99 (5), p.845-852
Main Authors: Park, Sunmin, Kim, Suhyun, Koun, Soonil, Park, Hae-Chul, Yoon, Won Sup, Rim, Chai Hong
Format: Article
Language:English
Subjects:
Amifostine
Animals
Intestines
Mistletoe
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Radiation-Protective Agents - pharmacology
Radiation-Protective Agents - therapeutic use
radioprotectant
radiotherapy
Zebrafish
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Summary:The intestine is a dose-limiting organ in the treatment of intra-abdominal cancer. We previously reported that the extract of mistletoe parasites on Quercus had a more potent radioprotective effect than amifostine in reducing the developmental toxicities of zebrafish embryos. In this study, radioprotection against intestinal toxicity was investigated in adult zebrafish. Wild-type adult AB zebrafish were exposed to 45-50 Gy of photon beam irradiation and/or treated with mistletoe extract orally 1 h before. The main endpoints of the study were survival and degree of deformation of the intestinal villi. The median follow-up period was 10 d post-irradiation (range: 7-11 d). A total of 105 zebrafish were used, including 42 in the radiation alone, 42 in the radiation and mistletoe arms, and 21 control subjects (mistletoe alone, mock-irradiated arm). The rate of both significant deformity and death was 53% in the radiation-alone arm, whereas the corresponding rate was 30% in the radiation and mistletoe arms. Significant deformity-free survival rates at 10 d post-irradiation in the radiation alone, and radiation and mistletoe arms were 44.7% (95% confidence interval [CI]:20-54.3) and 68.4% (95% CI:53.8-86.8), respectively (p=.046). The radiation and mistletoe arms showed decreased expression of two of three inflammatory genes (IL-1β and IL-6) compared to the radiation alone group (p
ISSN:0955-3002
1362-3095
DOI:10.1080/09553002.2023.2142982