In silico modelling of long bone healing involving osteoconduction and mechanical stimulation

A lot of evidence has shown the importance of stimulating cell mechanically during bone repair. In this study, we modeled the challenging fracture healing of a large bone defect in tibial diaphysis. To fill the fracture gap, we considered the implantation of a porous osteoconductive biomaterial made...

Full description

Saved in:
Bibliographic Details
Published in:Computer methods in biomechanics and biomedical engineering 2023-02, Vol.26 (2), p.174-186
Main Authors: Milan, Jean-Louis, Manifacier, Ian, Rousseau, Nicolas, Pithioux, Martine
Format: Article
Language:English
Subjects:
Biomaterials
Biomedical materials
Bone growth
Bone healing
Bone Regeneration - physiology
Computer Simulation
Diaphysis
Engineering Sciences
fracture gap
Fracture Healing - physiology
Healing
Humans
Hydrogels
Long bone
Mechanical loading
Mechanical stimuli
mechanoregulation
Osteoconduction
Osteogenesis
Periosteum
Polylactic acid
Rehabilitation
Surgical implants
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A lot of evidence has shown the importance of stimulating cell mechanically during bone repair. In this study, we modeled the challenging fracture healing of a large bone defect in tibial diaphysis. To fill the fracture gap, we considered the implantation of a porous osteoconductive biomaterial made of poly-lactic acid wrapped by a hydrogel membrane mimicking osteogenic properties of the periosteum. We identified the optimal loading case that best promotes the formation and differentiation into bone tissue. Our results support the idea that a patient's rehabilitation program should be adapted to reproduce optimal mechanical stimulations.
ISSN:1025-5842
1476-8259
DOI:10.1080/10255842.2022.2052051