Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells

The effects of asimilobine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells were investigated. Asimilobine at concentration ranges of 0.05-0.2 μM showed a significant inhibition of intracellular dopamine levels for 24 h in a concentration-de...

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Bibliographic Details
Published in:Journal of asian natural products research 2008-08, Vol.10 (8), p.737-745
Main Authors: Jin, Chun-Mei, Lee, Jae-Joon, Kim, Young-Kyoon, Ryu, Shi-Yong, Lim, Sung-Cil, Hwang, Bang-Yeon, Lee, Chong-Kil, Lee, Myung-Koo
Format: Article
Language:English
Subjects:
asimilobine
Biological and medical sciences
dopamine biosynthesis
General pharmacology
l-DOPA-induced cytotoxicity
Medical sciences
Neuropharmacology
Neuroprotective agent
PC12 cells
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
tyrosine hydroxylase
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