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New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense
Two new aporphine alkaloids, 6a -2'-(3-oxobutenyl)-thaliadin ( ) and -methylthalisopynine ( ), along with ten known analogs ( - ), were isolated from the roots of W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds...
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| Published in: | Journal of asian natural products research 2024-02, p.1-9 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 9 |
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| container_title | Journal of asian natural products research |
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| creator | Chen, Zhao-Jing Yang, Han-Gao Zhu, Wen-Peng Xue, Chun-Mei Zhang, Hong-Mei Peng, Yu-Ting Li, Da-Hong Hua, Hui-Ming |
| description | Two new aporphine alkaloids, 6a
-2'-(3-oxobutenyl)-thaliadin (
) and
-methylthalisopynine (
), along with ten known analogs (
-
), were isolated from the roots of
W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds
-
and
-
were tested for their antiproliferative effects
against two human cancer cell lines (A549 and MCF-7). Among them, compounds
,
and
exhibited moderate inhibitory activity against the tested cell lines with IC
values ranging from 23.73 to 34.97 μM. |
| doi_str_mv | 10.1080/10286020.2024.2317826 |
| format | article |
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-2'-(3-oxobutenyl)-thaliadin (
) and
-methylthalisopynine (
), along with ten known analogs (
-
), were isolated from the roots of
W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds
-
and
-
were tested for their antiproliferative effects
against two human cancer cell lines (A549 and MCF-7). Among them, compounds
,
and
exhibited moderate inhibitory activity against the tested cell lines with IC
values ranging from 23.73 to 34.97 μM.</description><identifier>ISSN: 1028-6020</identifier><identifier>EISSN: 1477-2213</identifier><identifier>DOI: 10.1080/10286020.2024.2317826</identifier><identifier>PMID: 38389314</identifier><language>eng</language><publisher>England</publisher><ispartof>Journal of asian natural products research, 2024-02, p.1-9</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c224t-bdaf14cfc5db788a93c97dd98f616ef0d1719b04c757f2b011a47dfc13007a153</cites><orcidid>0000-0002-6964-4619</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38389314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhao-Jing</creatorcontrib><creatorcontrib>Yang, Han-Gao</creatorcontrib><creatorcontrib>Zhu, Wen-Peng</creatorcontrib><creatorcontrib>Xue, Chun-Mei</creatorcontrib><creatorcontrib>Zhang, Hong-Mei</creatorcontrib><creatorcontrib>Peng, Yu-Ting</creatorcontrib><creatorcontrib>Li, Da-Hong</creatorcontrib><creatorcontrib>Hua, Hui-Ming</creatorcontrib><title>New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense</title><title>Journal of asian natural products research</title><addtitle>J Asian Nat Prod Res</addtitle><description>Two new aporphine alkaloids, 6a
-2'-(3-oxobutenyl)-thaliadin (
) and
-methylthalisopynine (
), along with ten known analogs (
-
), were isolated from the roots of
W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds
-
and
-
were tested for their antiproliferative effects
against two human cancer cell lines (A549 and MCF-7). Among them, compounds
,
and
exhibited moderate inhibitory activity against the tested cell lines with IC
values ranging from 23.73 to 34.97 μM.</description><issn>1028-6020</issn><issn>1477-2213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAURC0EoqXwCSD_QIqv7cTOElW8pAo2RSwjxw_FkNSR7VLx97Rqy2pmMWcWB6FbIHMgktwDobIilMwpoXxOGQhJqzM0BS5EQSmw813fbYr9aIKuUvoihAJU9BJNmGSyZsCn6PPNbrEaQxw7v7ZY9d-qD94kvPW5w2qdfd4MIWKls__x2duEXQwDzp3FMYSccHB41ane6xw3Aw6D9Xad7DW6cKpP9uaYM_Tx9LhavBTL9-fXxcOy0JTyXLRGOeDa6dK0QkpVM10LY2rpKqisIwYE1C3hWpTC0ZYAKC6M08AIEQpKNkPl4VfHkFK0rhmjH1T8bYA0e1HNSVSzF9UcRe24uwM3btrBmn_qZIb9AbQoZQk</recordid><startdate>20240222</startdate><enddate>20240222</enddate><creator>Chen, Zhao-Jing</creator><creator>Yang, Han-Gao</creator><creator>Zhu, Wen-Peng</creator><creator>Xue, Chun-Mei</creator><creator>Zhang, Hong-Mei</creator><creator>Peng, Yu-Ting</creator><creator>Li, Da-Hong</creator><creator>Hua, Hui-Ming</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6964-4619</orcidid></search><sort><creationdate>20240222</creationdate><title>New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense</title><author>Chen, Zhao-Jing ; Yang, Han-Gao ; Zhu, Wen-Peng ; Xue, Chun-Mei ; Zhang, Hong-Mei ; Peng, Yu-Ting ; Li, Da-Hong ; Hua, Hui-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c224t-bdaf14cfc5db788a93c97dd98f616ef0d1719b04c757f2b011a47dfc13007a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhao-Jing</creatorcontrib><creatorcontrib>Yang, Han-Gao</creatorcontrib><creatorcontrib>Zhu, Wen-Peng</creatorcontrib><creatorcontrib>Xue, Chun-Mei</creatorcontrib><creatorcontrib>Zhang, Hong-Mei</creatorcontrib><creatorcontrib>Peng, Yu-Ting</creatorcontrib><creatorcontrib>Li, Da-Hong</creatorcontrib><creatorcontrib>Hua, Hui-Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of asian natural products research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhao-Jing</au><au>Yang, Han-Gao</au><au>Zhu, Wen-Peng</au><au>Xue, Chun-Mei</au><au>Zhang, Hong-Mei</au><au>Peng, Yu-Ting</au><au>Li, Da-Hong</au><au>Hua, Hui-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense</atitle><jtitle>Journal of asian natural products research</jtitle><addtitle>J Asian Nat Prod Res</addtitle><date>2024-02-22</date><risdate>2024</risdate><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1028-6020</issn><eissn>1477-2213</eissn><abstract>Two new aporphine alkaloids, 6a
-2'-(3-oxobutenyl)-thaliadin (
) and
-methylthalisopynine (
), along with ten known analogs (
-
), were isolated from the roots of
W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds
-
and
-
were tested for their antiproliferative effects
against two human cancer cell lines (A549 and MCF-7). Among them, compounds
,
and
exhibited moderate inhibitory activity against the tested cell lines with IC
values ranging from 23.73 to 34.97 μM.</abstract><cop>England</cop><pmid>38389314</pmid><doi>10.1080/10286020.2024.2317826</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6964-4619</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1028-6020 |
| ispartof | Journal of asian natural products research, 2024-02, p.1-9 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1080_10286020_2024_2317826 |
| source | Taylor and Francis Science and Technology Collection |
| title | New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense |
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