Molecular forces governing protein-protein interaction: Structure-function relationship of complexes protein in the food industry

• Published in: Critical reviews in food science and nutrition 2022, Vol.62 (15), p.4036-4052
• Main Authors: Alrosan, Mohammad, Tan, Thuan-Chew, Easa, Azhar Mat, Gammoh, Sana, Alu'datt, Muhammad H.
• Format: Article
• Language: English
• Subjects: Food industry; Functional foods & nutraceuticals; functional properties; Ionic strength; Mixing ratio; Molecular forces; Molecular structure; Protein interaction; Protein structure; Proteins; proteins interaction; Structure-function relationships
• ISSN: 1040-8398; 1549-7852
• DOI: 10.1080/10408398.2021.1871589

The application of protein-protein interaction (PPI) has been widely used in various industries, such as food, nutraceutical, and pharmaceutical. A deeper understanding of PPI is needed, and the molecular forces governing proteins and their interaction must be explained. The design of new structures with improved functional properties, e.g., solubility, emulsion, and gelation, has been fueled by the development of structural and colloidal building blocks. In this review, the molecular forces of protein structures are discussed, followed by the relationship between molecular force and structure, ways of a bind of proteins together in solution or at the interface, and functional properties. A more detailed look is thus taken at the relationship between the various influencing factors on molecular forces involved in PPI. These factors include protein properties, such as types, concentration, and mixing ratio, and solvent conditions, such as ionic strength and pH. This review also summarizes methods tha1t are capable of identifying molecular forces in protein and PPI, as well as characterizing protein structure.