Heterocyclic Synthesis with Thiophene-2-Carboxamide

3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbo...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2008-01, Vol.183 (1), p.74-81
Main Author: Ahmed, Gamal A.
Format: Article
Language:English
Subjects:
dihydrothienopyrimidine
oxazinone
Tetrahydrothienopyrimidinone
thienopyrimidinedione
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Summary:3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Gram positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500701557005