Selection signatures of Qinchuan cattle based on whole-genome sequences

• Published in: Animal biotechnology 2023-11, Vol.34 (4), p.1483-1491
• Main Authors: Wang, Sihu, Raza, Sayed Haidar Abbas, Zhang, Ke, Mei, Chugang, Alamoudi, Muna O., Aloufi, Bandar H., Alshammari, Ahmed Mohajja, Zan, Linsen
• Format: Article
• Language: English
• Subjects: Animal breeding; Animal production; Annotations; Beef; Beef cattle; Body size; Breeding; Cattle; Gene sequencing; Genes; genome selection; Genomes; molecular genetic breeding; Protein interaction; Proteins; Qinchuan cattle; selective signature; Signatures; USH2A protein; Whole genome sequencing
• ISSN: 1049-5398; 1532-2378
• DOI: 10.1080/10495398.2022.2033252

Qinchuan cattle has gradually improved in body shape and growth rate in the long-term breeding process from the draft cattle to beef cattle. As the head of the five local yellow cattle in China, the Qinchuan cattle has been designated as a specialized beef cattle breed. We investigated the selection signatures using whole genome sequencing data in Qinchuan cattle. Based on Fst, we detected hundreds of candidate genes under selection across Qinchuan, Red Angus, and Japanese Black cattle. Through protein-protein interaction analysis and functional annotation of candidate genes, the results revealed that KMT2E, LTBP1 and NIPBL were related to brain size, body characteristics, and limb development, respectively, suggesting that these potential genes may affect the growth and development traits in Qinchuan cattle. ARIH2, DACT1 and DNM2, et al. are related to meat quality. Meanwhile, TBXA2R can be used as a gene associated with reproductive function, and USH2A affect coat color. This provided a glimpse into the formation of breeds and molecular genetic breeding. Our findings will promote genome-assisted breeding to improve animal production and health.