Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study

Increasing evidence suggests that hyperhomocysteinemia (HHcy) and hyperlipidemia have been recognized as two independent risks for cardiovascular disease. However, the association between hyperlipidemia and HHcy in hypertensive patients has not been systemically elucidated. The aim of this study was...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2021-01, Vol.43 (1), p.26-33
Main Authors: Chen, Jian, Li, Jing, Wang, Jia, Zeng, Dan, Zhang, Ying, Wu, Mengyi, Zhang, Dandan, Hong, Xiuqin
Format: Article
Language:English
Subjects:
Aged
Alanine Transaminase
Anthropometry
Blood Pressure
Blood Pressure Determination
Body Mass Index
China - epidemiology
Cholesterol - blood
Creatinine
Cross-Sectional Studies
Female
homocysteine (Hcy)
Humans
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - epidemiology
Hyperlipidemias - blood
Hyperlipidemias - epidemiology
Hypertension - blood
Hypertension - epidemiology
Hypertension - physiopathology
hypertension associated with hyperhomocysteinemia
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Lipoproteins, VLDL - blood
Male
Middle Aged
Risk Factors
Triglycerides - blood
Uric Acid - blood
Very low-density lipoprotein (VLDL)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Increasing evidence suggests that hyperhomocysteinemia (HHcy) and hyperlipidemia have been recognized as two independent risks for cardiovascular disease. However, the association between hyperlipidemia and HHcy in hypertensive patients has not been systemically elucidated. The aim of this study was to investigate the relation between very low-density lipoprotein (VLDL) and HHcy in hypertensive patients. From July 2013 to March 2014, a large cross-sectional study was performed using 4012 participants from urban and rural communities in Hunan province, China. Participants underwent accurate assessment of lipid profiles, homocysteine (Hcy), anthropometric, blood pressure, and other biochemical indicators. Among 1257 participants with hypertension, 626 (49.80%) were men and 631 (50.20%) were women. In total, 1081 (86.00%) of the participants were found to have HHcy, of which 559 (44.47%) were men and 522 (41.53%) were women. In the univariate analysis, the OR for patients with hypertension associated with hyperhomocysteinemia was significantly enhanced as the quartiles of the Log VLDL were increased. OR for quartile 4 was significantly higher than that for quartile 1 (OR = 3.7, 95% CI: 2.6-5.1; P
ISSN:1064-1963
1525-6006
DOI:10.1080/10641963.2020.1797084