Development of a Method to Evaluate the Release Profile of Tamoxifen from Pegylated Hybrid Micelles

Studies of in vitro release profiles are important during the development of drug delivery systems. This article describes the development and validation of a RP-HPLC method for the quantification of drug released from tamoxifen-loaded DSPE-PEG(2000)/TPGS micelles and the determination of the best d...

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Published in:Journal of liquid chromatography & related technologies 2015-07, Vol.38 (12), p.1223-1229
Main Authors: Claro de Souza, Marina, Marotta-Oliveira, Samantha Sant'Anna, Rocha, Nathália Helena Souza, Eloy, Josimar O., Marchetti, Juliana Maldonado
Format: Article
Language:English
Subjects:
analytical development and validation
drug delivery systems
hybrid pegylated micelles
in vitro release profile
RP-HPLC quantification
tamoxifen
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cited_by cdi_FETCH-LOGICAL-c338t-4bace8bd7e0693035f844dc32fe9ceb241073d4e36333eec5b99281a0ca2ca393
cites cdi_FETCH-LOGICAL-c338t-4bace8bd7e0693035f844dc32fe9ceb241073d4e36333eec5b99281a0ca2ca393
container_end_page 1229
container_issue 12
container_start_page 1223
container_title Journal of liquid chromatography & related technologies
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creator Claro de Souza, Marina
Marotta-Oliveira, Samantha Sant'Anna
Rocha, Nathália Helena Souza
Eloy, Josimar O.
Marchetti, Juliana Maldonado
description Studies of in vitro release profiles are important during the development of drug delivery systems. This article describes the development and validation of a RP-HPLC method for the quantification of drug released from tamoxifen-loaded DSPE-PEG(2000)/TPGS micelles and the determination of the best dissolution medium and apparatus for this assay. The method showed specificity, linearity, precision, accuracy, and robustness for the parameters evaluated (range 0.25-20.0 µg mL −1 ). The best dissolution medium was 1.0 mol L −1 sodium salicylate, pH 7.4, and the most suitable apparatus was a PVC tube with one end covered with a dialysis membrane. This method was shown to be useful for tamoxifen quantification in in vitro release studies.
doi_str_mv 10.1080/10826076.2015.1032418
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source Taylor and Francis Science and Technology Collection
subjects analytical development and validation
drug delivery systems
hybrid pegylated micelles
in vitro release profile
RP-HPLC quantification
tamoxifen
title Development of a Method to Evaluate the Release Profile of Tamoxifen from Pegylated Hybrid Micelles
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