Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats

The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the o...

Full description

Saved in:
Bibliographic Details
Published in:Archives of physiology and biochemistry 2020-05, Vol.126 (3), p.258-263
Main Authors: Gómez-Crisóstomo, N. P., De la Cruz-Hernández, E. N., Méndez Méndez, E. R., Hernández-Landero, M. F., Camacho Liévano, J. U., Martínez-Abundis, E.
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Animals
Cardiomegaly - blood
Diet induced obesity
Diet, High-Fat - adverse effects
Dietary Sugars - adverse effects
Energy Intake
Fructose - adverse effects
heart hypertrophy
hypercaloric diets
leptin
Leptin - blood
Leptin - metabolism
Male
obesity
Obesity - physiopathology
Overweight - physiopathology
Rats
Rats, Wistar
Risk Factors
Triglycerides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Only the HS group showed increased triglycerides levels after four months. Increased leptin levels were observed in HS and HF groups without changes on cardiac hypertrophy; on the opposing, HSHF group presented hypertrophy without the changes in serum leptin. The three experimental groups showed a decreased expression of leptin receptors ObR-b. In our results, the kind of diet for the induction of obesity is relevant for the outcome of the pathological profile.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2018.1517181