The effect of COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels in reproductive age women

The aim of this prospective cohort study was to investigate the effect of coronavirus disease 2019 (COVID-19) vaccinations on menstrual cycle and ovarian reserve in reproductive aged-women. Health care providers (n = 258) vaccinated with inactivated (CoronaVac) and mRNA based (Pfizer-BioNTech®) COVI...

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Bibliographic Details
Published in:Human fertility (Cambridge, England) England), 2023-01, Vol.26 (1), p.153-161
Main Authors: Hasdemir, Pinar Solmaz, Senol Akar, Sebnem, Goker, Asli, Kosova, Funda, Ucar, Duygu, Ozalp Ates, Funda Seher, Akcali, Sinem
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone
COVID-19 - prevention & control
COVID-19 vaccine
COVID-19 Vaccines
Female
Humans
Menstrual Cycle
Pfizer-biontech
Prospective Studies
SARS-CoV-2
sinovac-coronavac
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Summary:The aim of this prospective cohort study was to investigate the effect of coronavirus disease 2019 (COVID-19) vaccinations on menstrual cycle and ovarian reserve in reproductive aged-women. Health care providers (n = 258) vaccinated with inactivated (CoronaVac) and mRNA based (Pfizer-BioNTech®) COVID-19 vaccines were included. All subjects completed a gynaecological and menstrual history questionnaire and Anti-Mullerian Hormone (AMH) levels were measured in serum samples collected before first vaccination and at 1 st , 3 rd , 6 th and 9 th months. The prevalence of new-onset menstrual dysregulation following vaccination was 20.6% and it was statistically significant compared to baseline (p = 0.001). Menstrual pattern turned back to normal in 59.6% of vaccinated women. Serum AMH levels gradually decreased until 6 th month of follow-up compared to baseline (p 
ISSN:1464-7273
1742-8149
DOI:10.1080/14647273.2023.2181710