Paraoxonase-2 and paraoxonase-3: comparison of mRNA expressions in the placentae of unexplained intrauterine growth restricted and noncomplicated pregnancies

Objective: Recent evidence suggests that oxidative stress is involved in the pathophysiology of many human diseases. It has been demonstrated that oxidative stress is associated with intrauterine growth restriction (IUGR), and the depletion of placental antioxidant systems has been suggested as a ke...

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Published in:The journal of maternal-fetal & neonatal medicine 2017-05, Vol.30 (10), p.1200-1206
Main Authors: Dikbas, Levent, Yapca, Omer Erkan, Dikbas, Neslihan, Gundogdu, Cemal
Format: Article
Language:English
Subjects:
Adult
Aryldialkylphosphatase - genetics
Aryldialkylphosphatase - metabolism
Case-Control Studies
Female
Fetal Growth Retardation - enzymology
Fetal Growth Retardation - etiology
Humans
IUGR
mRNA
Oxidative Stress
Placenta - enzymology
placentae
PON2
PON3
Pregnancy
Real-Time Polymerase Chain Reaction
RNA, Messenger - metabolism
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Summary:Objective: Recent evidence suggests that oxidative stress is involved in the pathophysiology of many human diseases. It has been demonstrated that oxidative stress is associated with intrauterine growth restriction (IUGR), and the depletion of placental antioxidant systems has been suggested as a key factor in this disease. Our aims were to explore the possible role of antioxidant paraoxonase-2 (PON2) and paraoxonase-3 (PON3) in the pathophysiology of unexplained IUGR. Methods: We have studied the expression of mRNA for PON2, PON3 in placental tissues by using RT-qPCR. Two groups, consisting of normal (n = 18) and unexplained IUGR pregnancies (n = 20) were compared. Results: Our results demonstrated that there were no significant differences in the mRNA expressions of PON2, PON3 between the two groups (p = 0.28, p = 0.90, respectively). PON2 and PON3 were down-regulated in IUGR. Antenatal steroid therapy had no effect on the expression mRNA in placentae of unexplained IUGR pregnancies compared to non-treated group. Conclusions: These results suggest that PON2, PON3 mRNA levels were not changed significantly in placentae of IUGR when compared to normal pregnant women.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2016.1209480