The effects of chromosome polymorphism on the clinical outcomes of in vitro fertilization/embryo transfer-assisted reproduction

To investigate the effects of chromosome polymorphism on the clinical outcomes of in vitro fertilization/embryo transfer (IVF/ET)-assisted reproductive technology. The case data of 2740 patients treated between January 2018 and January 2019 were retrospectively analyzed. The patients were organized...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2023-12, Vol.36 (2), p.2238863-2238863
Main Authors: Zhang, Xiu-ping, Zhang, Ying-feng, Liang, Li-xia, Zhang, Zhi-ping, Wu, Yuan-Xia, Zhang, Xue-luo, Wu, Xue-qing
Format: Article
Language:English
Subjects:
assisted reproductive technology
Chromosome polymorphism
Chromosomes
clinical pregnancy rate
embryo transfer
Embryo Transfer - adverse effects
Female
Fertilization in Vitro - adverse effects
Humans
in vitro fertilization
Live Birth
live birth rate
Pregnancy
Pregnancy Rate
Pregnancy, Multiple
Retrospective Studies
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Summary:To investigate the effects of chromosome polymorphism on the clinical outcomes of in vitro fertilization/embryo transfer (IVF/ET)-assisted reproductive technology. The case data of 2740 patients treated between January 2018 and January 2019 were retrospectively analyzed. The patients were organized into two groups: a case group and a control group. In the case group (n = 81), one or both parents were characterized by chromosomal polymorphism; in the control group (n = 2659), both parents had normal chromosome karyotyping. The primary outcomes included clinical pregnancy rate (clinical pregnancy rate of fresh transfer cycles = number of clinical pregnancy cycles/number of fresh embryo transfer cycles × 100%) and live birth rate (live birth rate per fresh transfer cycles = number of live births/numbers of fresh embryo transfer cycles × 100%). The propensity score matching (PSM) method was used for statistical analysis. After PSM 1:2 matching for the patients in the two groups, 72 patients were successfully matched. The clinical pregnancy rate and live birth rate in the case group were lower than in the control group before PSM (clinical pregnancy rate: 33.30% case group vs. 46.60% control group, p = .020; live birth rate: 30.90% case group vs. 47.90% control group, p = .03). The differences were statistically significant (p 
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2023.2238863