Dimeric γ-lactone derivatives from the soil-derived fungus Lasiodiplodia theobromae NSTRU-PN1.4

Investigation of the soil-derived fungus Lasiodiplodia theobromae NSTRU-PN1.4 resulted in the isolation of five dimeric γ-lactones including two new botryosphaerilactones D and E (4 and 5) and three known structurally related analogoues (1-3) along with seven known compounds. Their structures were e...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2022-04, Vol.36 (8), p.1948-1958
Main Authors: Arunpanichlert, Jiraporn, Rukachaisirikul, Vatcharin, Chaiwarin, Titima, Tantirungrotechai, Yuthana, Khamthong, Nanthaphong, Phongpaichit, Souwalak, Liamthong, Sumalee, Sakayaroj, Jariya
Format: Article
Language:English
Subjects:
antifungal activity
Ascomycota - chemistry
dimeric γ-lactone
Lactones - chemistry
Lasiodiplodia theobromae
Soil
Soil-derived fungus
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Investigation of the soil-derived fungus Lasiodiplodia theobromae NSTRU-PN1.4 resulted in the isolation of five dimeric γ-lactones including two new botryosphaerilactones D and E (4 and 5) and three known structurally related analogoues (1-3) along with seven known compounds. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1-5 was determined by comparison of the ECD data with those of the structurally related monomeric γ-lactones. For biological evaluation, this is the first report on antifungal activity of the known (3 R,4R)-4-acetyl-3-methyl-2(3H)-dihydrofuranone which displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 200 µg/mL.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1837821