Participation of voltage-gated sodium and calcium channels in the acute cardiac effects of toluene

Inhaling solvents can lead to occurrence of cardiac arrhythmias and sudden sniffing death. Mechanisms related to this phenomenon are not fully understood. The purpose of this study was to investigate the effect of acute toluene exposure on heart reactivity to epinephrine and the participation of vol...

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Bibliographic Details
Published in:Toxicology mechanisms and methods 2018-11, Vol.28 (9), p.670-677
Main Authors: Carreón-Garcidueñas, M., Godínez-Hernández, D., Alvarado-Gómez, N., Ortega-Varela, L. F., Cervantes-Durán, C., Gauthereau-Torres, M. Y.
Format: Article
Language:English
Subjects:
Animals
arrhythmias
calcium channels
Calcium Channels, L-Type - biosynthesis
Calcium Channels, L-Type - metabolism
Coronary Circulation - drug effects
Dose-Response Relationship, Drug
epinephrine
Epinephrine - pharmacology
Heart Function Tests
Heart Rate - drug effects
Heart Ventricles - drug effects
Heart Ventricles - metabolism
Inhalation Exposure
Male
NAV1.5 Voltage-Gated Sodium Channel - biosynthesis
NAV1.5 Voltage-Gated Sodium Channel - metabolism
Rats, Wistar
sodium channels
Solvents - toxicity
Toluene
Toluene - toxicity
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Summary:Inhaling solvents can lead to occurrence of cardiac arrhythmias and sudden sniffing death. Mechanisms related to this phenomenon are not fully understood. The purpose of this study was to investigate the effect of acute toluene exposure on heart reactivity to epinephrine and the participation of voltage-gated sodium and calcium channels. We found that acute toluene exposure increased perfusion pressure, left ventricular developed pressure, and heart rate. These actions were inhibited by lidocaine and nifedipine. Our results suggest that acute toluene exposure modify voltage-gated sodium and calcium channel function and expression likely due to a cardiac adrenergic mechanism and these effects could be participating, at least in part, in the presence of cardiac arrhythmias. To our best knowledge, this is the first report to establish a direct participation of voltage-gated Na + and Ca 2+ channels, toluene and epinephrine on cardiac function in rats.
ISSN:1537-6516
1537-6524
DOI:10.1080/15376516.2018.1491664