CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients

Background: Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least six weeks. Multifactorial origin is suggested such as oxidative stress. This latter may play a double role as a trigger and remnant agent. O...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2017-10, Vol.36 (4), p.387-392
Main Authors: Maouia, A., Youssef, M., Leban, N., Ben Chibani, J., Helal, A. N., Kassab, A.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
C-Reactive Protein - analysis
Catalase - blood
Chronic Disease
Chronic spontaneous urticaria
desloratadine
Female
Glutathione Peroxidase - blood
Glutathione Transferase - blood
Histamine H1 Antagonists, Non-Sedating - pharmacology
Histamine H1 Antagonists, Non-Sedating - therapeutic use
Humans
inflammation
Loratadine - analogs & derivatives
Loratadine - pharmacology
Loratadine - therapeutic use
Male
Middle Aged
oxidative stress
Severity of Illness Index
Superoxide Dismutase - blood
Tunisia
Urticaria - blood
Urticaria - drug therapy
Urticaria - pathology
Young Adult
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Summary:Background: Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least six weeks. Multifactorial origin is suggested such as oxidative stress. This latter may play a double role as a trigger and remnant agent. Objectives: The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: desloratadine 5 mg/d on these different parameters. Patients and Methods: This study enrolled 30 CSU patients and same number of controls. We assessed the urticaria activity score (UAS), total antioxidant status (TAS), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), albumin, alpha1, alpha2, beta1 beta2, gamma globulins, c-reactive protein (CRP) and hematologic numeration. Results: At baseline alpha1, alpha2, beta1, beta2, gamma globulins, CRP, SOD activity, leukocytes and basophils were significantly higher in patients versus controls (p 
ISSN:1556-9527
1556-9535
DOI:10.1080/15569527.2017.1311338