A Double-Blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients

We report a randomized, double-blind, multicenter trial in which amphotericin B colloidal dispersion (ABCD [Amphotec]; 6 mg/kg/day) was compared with amphotericin B (AmB; 1.0–1.5 mg/kg/day) for the treatment of invasive aspergillosis in 174 patients. For evaluable patients in the ABCD and AmB treatm...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2002-08, Vol.35 (4), p.359-366
Main Authors: Bowden, Raleigh, Chandrasekar, Pranatharthi, White, Mary H, Li, Xin, Pietrelli, Larry, Gurwith, Marc, van Burik, Jo-Anne, Laverdiere, Michel, Safrin, Sharon, Wingard, John R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Amphotericin B - adverse effects
Amphotericin B - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - adverse effects
Antifungal Agents - therapeutic use
Antifungals
Aspergillosis
Aspergillosis - drug therapy
Aspergillosis - mortality
Biological and medical sciences
Bone marrow
Child
Child, Preschool
Dosage
Double-Blind Method
Drug Delivery Systems
Fever
Fungal infections
Humans
Immunocompromised Host
Infections
Major Articles
Medical sciences
Medical treatment
Middle Aged
Mortality
Nephrotoxicity
Pharmacology. Drug treatments
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a randomized, double-blind, multicenter trial in which amphotericin B colloidal dispersion (ABCD [Amphotec]; 6 mg/kg/day) was compared with amphotericin B (AmB; 1.0–1.5 mg/kg/day) for the treatment of invasive aspergillosis in 174 patients. For evaluable patients in the ABCD and AmB treatment groups, respective rates of therapeutic response (52% vs. 51%; P = 1.0), mortality (36% vs. 45%; P =.4), and death due to fungal infection (32% vs. 26%; P =.7) were similar. Renal toxicity was lower (25% vs. 49%; P =.002) and the median time to onset of nephrotoxicity was longer (301 vs. 22 days; P
ISSN:1058-4838
1537-6591
DOI:10.1086/341401