Effects of vaccination on dengue transmission dynamics

Around 390 million dengue cases happen annually and two thirds of the world's population are at risk of attracting dengue. Dengue is caused by four distinct serotypes where infection by one of the serotypes provides lifelong immunity to that serotype but has a higher chance of attracting the mo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physics. Conference series 2020-03, Vol.1490 (1), p.12048
Main Authors: Ndii, Meksianis Z., Messakh, Jakobis J., Djahi, Bertha S.
Format: Article
Language:English
Subjects:
Dengue fever
Infections
Physics
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Around 390 million dengue cases happen annually and two thirds of the world's population are at risk of attracting dengue. Dengue is caused by four distinct serotypes where infection by one of the serotypes provides lifelong immunity to that serotype but has a higher chance of attracting the more dangerous forms of dengue (Dengue Hemorrhagic Fever(DHF) or Dengue Shock Syndrome (DSS)) in subsequent infections. Therefore, a perfect strategy against all dengue serotypes is required to reduce the number of dengue infections. A dengue vaccine with the efficacy of 54-77% has been approved for use in reducing dengue transmission. The use of this 'imperfect' vaccine may increase the possibility of individuals to attract DHF or DSS. Using a deterministic mathematical model, we assess the impact of the use of dengue vaccine. The results showed that vaccinating seronegative individuals may increase the number of secondary infections. On the other hand, the number of secondary infections decrease if we vaccinate seropositive individuals. This indicates that the risk of attracting DHF or DSS increases if we vaccinate seronegative individuals. Our results imply that the vaccination program may be successful when we vaccinate seropositive individuals.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1490/1/012048