Urinary Excretion of Steroids During Carbon Tetrachloride Intoxication in Rats

In this study the action of carbon tetrachloride on the adrenal cortex was investigated. This was done by measuring the 17-KS and 17-OH in the urine of a group of rats which had been subjected to subtoxic doses of carbon tetrachloride over a period of time. A considerable increase in the amounts of...

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Bibliographic Details
Published in:The Annals of occupational hygiene 1968-01, Vol.11 (1), p.33-35
Main Authors: Eliakis, C., Eliakis, E., Coutselinis, A., Kiaris, H.
Format: Article
Language:English
Subjects:
17-Hydroxycorticosteroids - urine
17-Ketosteroids - urine
Adrenal Glands - drug effects
Animals
Carbon Tetrachloride Poisoning - urine
Female
Male
Rats
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Summary:In this study the action of carbon tetrachloride on the adrenal cortex was investigated. This was done by measuring the 17-KS and 17-OH in the urine of a group of rats which had been subjected to subtoxic doses of carbon tetrachloride over a period of time. A considerable increase in the amounts of both the 17-KS and 17-OH was observed indicating that carbon tetrachloride probably acts on adrenal cortex indirectly through the hypothalamus and the pituitary gland.
ISSN:0003-4878
1475-3162
1475-3162
DOI:10.1093/annhyg/11.1.33